Functional abdominal pain

Mother and child Functional abdominal pain

Lactobacillus reuteri DSM 17938 in the Treatment of Functional Abdominal Pain in Children: RCT Study

Background: Beneficial therapeutic effect of probiotics has been reported in children with the irritable bowel syndrome (IBS) but not consistently in other functional abdominal pain-related disorders. The aim of the present study was to investigate the effect of Lactobacillus reuteri DSM 17938 in the treatment of functional abdominal pain (FAP) and IBS in children. Methods: […]

Author: Jadrešin O Year: 2017

Mother and child Functional abdominal pain

Lactobacillus reuteri DSM 17938 is effective in the treatment of functional abdominal pain in children: Results of the double-blind randomized study

Background: Possible therapeutic effect of Lactobacillus (L.) reuteri DSM 17938 has been reported in children with functional abdominal pain (FAP) but data are inconclusive. Methods: This is a randomized double-blinded controlled trial (RCT) which assessed effect of L. reuteri DSM 17938 (dose 108 CFU/day) in children (age 4-18 years) on FAP during an intervention period […]

Author: Jadrešin O Year: 2020

Mother and child Functional abdominal pain

Use of probiotics in the treatment of functional abdominal pain in children

Background: Functional abdominal pain is a very frequent functional gastrointestinal disorder but still without adequate treatment options. Therefore, the main aim of this systematic review and meta-analysis was to evaluate strain-specific probiotic effects on functional abdominal pain in children. Methods: This was a systematic review and meta-analysis of randomized controlled trials published in a period […]

Author: I Trivić Year: 2021

Mother and child Functional abdominal pain

Lactobacillus reuteri in children with Functional Abdominal Pain

Background: Functional abdominal pain (FAP) is a frequent condition affecting 10-20% of children and can be considered within the classification of functional gastrointestinal disorders (FGID). The objective of this study was to determine the effect of daily supplementation with the probiotic Lactobacillus reuteri DSM 17938 in children with FAP. Methods: The children (aged 6-16 years) […]

Author: Romano C Year: 2014

Mother and child Functional abdominal pain

Lactobacillus reuteri for the management of Functional Abdominal Pain in children

Background: To determine whether administration of Lactobacillus reuteri DSM 17938 is beneficial in functional abdominal pain (FAP) of childhood. Method: A total of 101 children, aged 6-15 years, who fulfilled the Rome III criteria for FAP were enrolled in a randomized double-blind, placebo-controlled trial, and were randomly assigned to receive either L. reuteri DSM 17938 […]

Author: Weizman Z Year: 2016

Constipation

Mother and child Constipation

Lactobacillus reuteri in infants with functional chronic constipation

Background: Constipation is a common and distressing pediatric problem, with a prevalence ranging from 7% to 30% in both western and non-western countries. There is growing interest in the use of probiotics in organic and functional gastrointestinal disorders. Probiotics are reported to be effective in the treatment of inflammatory bowel disease, traveller diarrhea, and constipation. […]

Author: Coccorullo P Year: 2010

Mother and child Constipation

Lactobacillus reuteri and Magnesium Oxide in Children with Functional Chronic Constipation

Background: Chronic functional constipation is a frequent condition. The aim of the study was to evaluate the efficacy of the probiotic Lactobacillus (L.) reuteri DSM 17938 and magnesium oxide (MgO) for relieving chronic functional constipation in children. Methods: A prospective, double-blind, placebo-controlled, randomized, and parallel-group trial was conducted in five pediatric outpatient clinics in Japan. […]

Author: Kubota M Year: 2020

Acute gastroenteritis

Mother and child Acute gastroenteritis

Lactobacillus reuteri vs. placebo in children with acute diarrhoea

Background: Probiotics may be of help for the management of acute diarrhoea, however, the effect is strain specific and efficacy needs to be proven. Aim: To test the efficacy and safety of Lactobacillus reuteri DSM 17938 derived from L. reuteri ATCC 55730 in children with acute diarrhoea. Primary outcomes were the rate of unresolved diarrhoea after 3 […]

Author: Francavilla R Year: 2012

Mother and child Acute gastroenteritis

Lactobacillus reuteri effectively reduces the duration of acute diarrhoea in hospitalised children

Background: Guidelines consider certain probiotics useful in the management of acute gastroenteritis. This study evaluated the use of Lactobacillus (L) reuteri DSM 17938. Methods: A multicentre, randomised, single-blind clinical trial was performed in hospitalised children with acute gastroenteritis lasting 12-72 h. Children received conventional therapy with, or without, 1 × 108 CFU of L. reuteri DSM […]

Author: Dinleyici EC Year: 2014

Mother and child Acute gastroenteritis

Lactobacillus reuteri shortens acute infectious diarrhea in a pediatric outpatient setting

Background: Two randomized controlled clinical trials have shown that Lactobacillus (L) reuteri DSM 17938 reduces the duration of diarrhea in children hospitalized due to acute infectious diarrhea. This was the first trial evaluating the efficacy of L. reuteri DSM 17938 in outpatient children with acute infectious diarrhea. Methods: This was a multicenter, randomized, single-blinded, case control […]

Author: Dinleyici EC Year: 2015

Mother and child Acute gastroenteritis

Lactobacillus reuteri strain for treating acute gastroenteritis in children

Background: Lactobacillus reuteri ATCC 55730 has been shown to provide a moderate clinical effect in the treatment of acute gastroenteritis (AGE) in children. However, as the L. reuteri ATCC 55730 strain was found to carry potentially transferable resistance traits for tetracycline and lincomycin, it was replaced by a new strain, L. reuteri DSM 17938, without […]

Author: Szajewska H Year: 2014

Infection protection

Mother and child Infection protection

Effect of a probiotic infant formula on infections in child care centers

Objective: To investigate the effect of 2 different species of probiotics in preventing infections in infants attending child care centers. Methods: A double-blind, placebo-controlled, randomized trial was conducted from December 1, 2000, to September 30, 2002, at 14 child care centers in the Beer-Sheva area of Israel in healthy term infants 4 to 10 months old. Infants […]

Author: Weizman Z Year: 2005

Mother and child Infection protection

Probiotics and calcium in diarrhea and respiratory tract infections in children

Objective: To investigate the effects of calcium and probiotics on the incidence and duration of acute diarrhea and acute respiratory tract infections (ARTIs) in low-socioeconomic communities of Jakarta, Indonesia. Methods: We conducted a 6-month, double-blind, placebo-controlled study in 494 healthy children aged 1 to 6 years who received low-lactose milk with low calcium content (LC; ∼50 mg/day; […]

Author: Agustina R Year: 2012

Mother and child Infection protection

Diarrhea in preschool children and Lactobacillus reuteri

Objectives: To evaluate whether daily administration of Lactobacillus reuteri DSM 17938 reduces the frequency and duration of diarrheal episodes and other health outcomes in day school children in Mexico. Methods: Healthy children (born at term, aged 6-36 months) attending day care centers were enrolled in this randomized, double-blind, placebo-controlled trial. They received L. reuteri DSM 17938 108 […]

Author: Gutiérrez-Castrellón P Year: 2014

Colic

Mother and child Colic, Constipation, Regurgitation

Lactobacillus reuteri in the prevention of colic, regurgitation, and functional constipation

Background: Infantile colic, gastroesophageal reflux, and constipation are the most common functional gastrointestinal disorders that lead to referral to a pediatrician during the first 6 months of life and are often responsible for hospitalization, feeding changes, use of drugs, parental anxiety, and loss of parental working days with relevant social consequences. Objective: To investigate whether oral […]

Author: Indrio F Year: 2014

Mother and child Colic

Efficacy of Lactobacillus reuteri for infantile colic

Background: 5% to 40% of infants cry excessively, usually accompanied by fussiness and excessive of gas. There are no uniform criteria for treatment of infantile colic. Lactobacillus reuteri DSM 17938 has been used with promising results. The objective of this network-meta-analysis (NMA) is to compare the efficacy of L. reuteri DSM 17938 with other interventions […]

Author: Gutiérrez-Castrellón P Year: 2017

Mother and child Colic

Lactobacillus reuteri to treat infant colic

Background: Lactobacillus reuteri DSM17938 has shown promise in managing colic, but conflicting study results have prevented a consensus on whether it is truly effective. Through an individual participant data meta-analysis, we sought to definitively determine if L. reuteri DSM17938 effectively reduces crying and/or fussing time in infants with colic and whether effects vary by feeding type. […]

Author: Sung V Year: 2018

Mother and child Colic

Lactobacillus reuteri in infantile colic

Objective: To test the efficacy of Lactobacillus reuteri on infantile colic and to evaluate its relationship to the gut microbiota. Study design: Fifty exclusively breastfed colicky infants, diagnosed according to modified Wessel’s criteria, were randomly assigned to receive either L. reuteri DSM 17 938 (108 colony-forming units) or placebo daily for 21 days. Parental questionnaires […]

Author: Savino F Year: 2010

Mother and child Colic

Lactobacillus reuteri versus simethicone in the treatment of infantile colic

Objective: The goal was to test the hypothesis that oral administration of Lactobacillus reuteri in a prospective randomized study would improve symptoms of infantile colic. Methods: Ninety breastfed colicky infants were assigned randomly to receive either the probiotic L. reuteri (108) live bacteria per day) or simethicone (60 mg/day) each day for 28 days. The […]

Author: Savino F Year: 2007

Mother and child Colic

Lactobacillus reuteri for the management of infantile colic in breastfed infants

Objective: To determine whether administration of Lactobacillus reuteri (L. reuteri) DSM 17938 is beneficial in breastfed infants with infantile colic. Study design: Eighty infants aged <5 months with infantile colic (defined as crying episodes lasting 3 or more hours per day and occurring at least 3 days per week within 7 days prior to enrollment), […]

Author: Szajewska H Year: 2013

Mother and child Colic

Lactobacillus reuteri for infantile colic

Objective: To investigate the effectiveness of Lactobacillus reuteri DSM 17938 for the treatment of infantile colic in breastfed Canadian infants, compared with placebo. Study design: A randomized, double-blind, placebo-controlled trial was conducted involving 52 infants with colic, according to modified Wessel criteria, who were assigned at random to receive L. reuteri DSM 17938 (108 colony-forming […]

Author: Chau K Year: 2015

Mother and child Colic

Lactobacillus reuteri in infantile colic and colicky induced maternal depression

Background: Infant colic, excessive crying of unknown cause, is a major burden to families and effects about 10-30 % of infants. Despite decades of research, the exact cause and treatment of infant colic has remained elusive. Objective: The use of Lactobacillus reuteri (DSM 17938) in infant colic is somewhat controversial and hence, we designed this […]

Author: Mi GL Year: 2015

Mother and child Colic

Preventive effects of Lactobacillus reuteri on infantile colic

Background: Recent studies have shown that colicky infants’ gut microbiota is characterised by a low amount of lactobacilli and an increased amount of coliform bacteria and this issue has been reported as a possible cause of gut dysmotility and increasing of flatulence production. In the last years many scientists have suggested the usefulness of vitamin […]

Author: Savino F Year: 2015

Mother and child Colic

The efficacy of Lactobacillus reuteri in infants and children

Background: The aim of this review was to systematically review and update evidence on the efficacy and safety of using L. reuteri DSM 17938, regardless of the indication, in infants and children. The choice of the probiotic strain was determined by the facts that it is widely available and it is commonly used in the […]

Author: Urbańska M Year: 2014

Regurgitation

Mother and child Regurgitation

Lactobacillus reuteri accelerates gastric emptying and improves regurgitation in infants

Background: Young infants are frequently affected by uncomplicated regurgitation that may persist despite dietetic and conservative interventions. On this basis, we studied the putative effects of probiotics on the frequency of regurgitation and gastric emptying time in infants with functional gastroesophageal reflux (GER). Methods: Forty-two infants with regurgitation were randomized to assume Lactobacillus reuteri DSM […]

Author: Indrio F Year: 2011

Allergy prevention

Mother and child Allergy prevention

Lactobacillus reuteri effect on immune maturation and allergy development

Background: Perinatal childhood exposures, including probiotic supplementation, may affect epigenetic modifications and impact on immune maturation and allergy development. The aim of this study was to assess the effects of pre- and postnatal Lactobacillus reuteri supplementation on DNA methylation in relation to immune maturation and allergy development. Methods: DNA methylation patterns were investigated for allergy-related […]

Author: A Forsberg Year: 2020

Mother and child Allergy prevention

Immunomodulatory effects by probiotics and ω-3 fatty acids during pregnancy

Background: Allergic diseases have become a major health problem, partly due to reduced microbial stimulation and a decreased dietary ω-3/ω-6 long-chain polyunsaturated fatty acid ratio. Prenatal exposures have been reported to influence allergy development, possibly induced via changes in maternal immune regulation. Methods: In a randomized double-blind placebo-controlled multicenter allergy prevention trial (PROOM-3), pregnant women […]

Author: Forsberg A Year: 2020

Mother and child Allergy prevention

Lactobacillus reuteri in prevention of IgE-associated eczema

Background: An altered microbial exposure may underlie the increase of allergic diseases in affluent societies. Probiotics may alleviate and even prevent eczema in infants. Objective: To prevent eczema and sensitization in infants with a family history of allergic disease by oral supplementation with the probiotic Lactobacillus reuteri. Methods: Double-blind, randomized, placebo-controlled trial, which comprised 232 […]

Author: Abrahamsson TR Year: 2007

Gingivitis

Mother and child Gingivitis, Pregnancy gingivitis

Lactobacillus reuteri lozenges reduces pregnancy gingivitis

Aim: This randomized controlled trial assessed the impact of Lactobacillus reuteri on pregnancy gingivitis in healthy women. Materials and methods: Forty-five healthy women (24 test/21 placebo) with pregnancy gingivitis in the third trimester of pregnancy were enrolled. At baseline Gingival Index (GI) and Plaque Index (PlI) were assessed at the Ramfjord teeth and venous blood […]

Author: Schlagenhauf Year: 2016